Outcome Prediction in Hodgkin Lymphoma by Low-Density Gene Expression Profiling of Formalin Fixed Paraffin Embedded Tissues: A Correlative Study of Inter-Group Trial E2496
- To explore the predictive power of a gene expression-based multi-gene predictor in
classical Hodgkin lymphoma (cHL) with the potential to change clinical practice by
basing treatment decisions on biological markers.
OUTLINE: Archived tissue samples are analyzed for gene expression profile using NanoString
technology. Results are then compared with patients' treatment outcomes, including
failure-free survival and overall survival.
PROJECTED ACCRUAL: A total of 306 patients from ECOG-2496 (training cohort) and 87 patients
treated with ABVD in other trials (validation cohort) will be accrued for this study.
Potential of gene expression profiling in changing treatment decision in cHL
Randall D. Gascoyne, MD
British Columbia Cancer Agency
United States: Federal Government