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Micro RNA Expression Analysis in B-Lineage Adult Acute Lymphoblastic Leukemia From ALL Trial, E2993, Including Patients With Various Cytogenetic and Molecular Abnormalities


N/A
15 Years
65 Years
Not Enrolling
Both
Leukemia

Thank you

Trial Information

Micro RNA Expression Analysis in B-Lineage Adult Acute Lymphoblastic Leukemia From ALL Trial, E2993, Including Patients With Various Cytogenetic and Molecular Abnormalities


OBJECTIVES:

- To identify microRNAs that behave as oncogenes or as tumor suppressor genes in
B-lineage acute lymphoblastic leukemia (ALL) in vitro and in vivo.

- To examine if single microRNA or signatures of microRNA correspond to different
clinical outcomes in cytogenetically distinct B-ALL groups.

OUTLINE: RNA from archived samples are analyzed for microRNA expression profile in vitro and
in vivo.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Samples from patients enrolled on ECOG-2993

- Samples from patients with recurrent cytogenetic abnormalities other than BCR-ABL,
including MLL/AF4, E2A/PBX1, and TEL/AML1

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Comprehensive view of microRNA expression by cytogenetic subgroup

Safety Issue:

No

Principal Investigator

Hans-Guido Wendel, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

Unspecified

Study ID:

CDR0000720304

NCT ID:

NCT01505699

Start Date:

March 2012

Completion Date:

Related Keywords:

  • Leukemia
  • adult acute lymphoblastic leukemia in remission
  • B-cell adult acute lymphoblastic leukemia
  • Burkitt Lymphoma
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

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