Micro RNA Expression Analysis in B-Lineage Adult Acute Lymphoblastic Leukemia From ALL Trial, E2993, Including Patients With Various Cytogenetic and Molecular Abnormalities
- To identify microRNAs that behave as oncogenes or as tumor suppressor genes in
B-lineage acute lymphoblastic leukemia (ALL) in vitro and in vivo.
- To examine if single microRNA or signatures of microRNA correspond to different
clinical outcomes in cytogenetically distinct B-ALL groups.
OUTLINE: RNA from archived samples are analyzed for microRNA expression profile in vitro and
Comprehensive view of microRNA expression by cytogenetic subgroup
Hans-Guido Wendel, MD
Memorial Sloan-Kettering Cancer Center