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Evaluation of the Diagnostic Utility of Serum Dexamethasone Measurements in the Overnight 1mg Dexamethasone Suppression Test in Patients Investigated for Cushing's Syndrome and Incidentalomas


Phase 3
18 Years
N/A
Open (Enrolling)
Both
Cushing's Syndrome, Adrenal Incidentalomas, Alcoholism, Obesity

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Trial Information

Evaluation of the Diagnostic Utility of Serum Dexamethasone Measurements in the Overnight 1mg Dexamethasone Suppression Test in Patients Investigated for Cushing's Syndrome and Incidentalomas


Inclusion Criteria:



- Age over 18 years

- Under investigation for hypercortisolism

- Able and willing to make informed consent

Exclusion Criteria:

- Use of systemic or local glucocorticoids

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

The difference (in percent) in false positive DXM-tests comparing the outcome of all tests with all tests excluding those with s-DXM below the the cut-off specified below.

Outcome Description:

The s-DXM cut-off will be defined a priori from ROC analysis on patients that inadequately suppress s-cortisol categorized as having Cushing's syndrome or being healthy. DXM, dexamethasone; DXM-test, short 1mg dexamethasone suppression test.

Outcome Time Frame:

1 year

Safety Issue:

No

Principal Investigator

Grethe Åstrøm Ueland, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Haukeland University Hospital

Authority:

Norway: Regional Ethics Commitee

Study ID:

2011/1810

NCT ID:

NCT01504555

Start Date:

October 2011

Completion Date:

December 2012

Related Keywords:

  • Cushing's Syndrome
  • Adrenal Incidentalomas
  • Alcoholism
  • Obesity
  • hypercortisolism, dexamethasone, alcoholism,obesity.
  • Alcoholism
  • Cushing Syndrome
  • Obesity
  • Adrenocortical Adenoma
  • Adrenal Gland Neoplasms

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