Genomics of Small Cell Lung Carcinoma
18 Years
N/A
Both
Lung Cancer
Trial Information
Genomics of Small Cell Lung Carcinoma
OBJECTIVES:
Primary
- To identify the major genetic alterations in human small cell lung cancer (SCLC) using
next-generation sequencing and focusing on mutations in coding sequence.
Secondary
- To follow up with in-depth assessment of candidate oncogenes and tumor suppressor genes
using gene expression analysis, cell culture systems, and murine models of SCLC.
OUTLINE: DNA isolated from archived tumor tissue and blood samples are analyzed for genetic
mutations and gene expression profiling using Illumina exome sequencing. Results are
compared with transcriptome of tumors (or cell lines) with and without the specific
mutation. Cell culture studies overexpressing or inhibiting the genes of interest are also
performed in a mouse model to identified potential drivers of small cell lung cancer.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Patients must have been registered to CALGB-140202 trial in which tumor material
(frozen tissue and paired blood specimens) is available
- IRB review and approval at the institution where the laboratory work will be
performed is required
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Identification of genetic alterations in human SCLC (driver or passenger mutations)
Safety Issue:
No
Principal Investigator
David MacPherson, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Carnegie Institution for Science
Authority:
Unspecified
Study ID:
CDR0000721552
NCT ID:
NCT01503619
Start Date:
February 2012
Completion Date:
Related Keywords:
- Lung Cancer
- small cell lung cancer
- Lung Neoplasms
- Small Cell Lung Carcinoma
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