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A Translational Study of the Interactions Between Prior Pregnancy and the Biologic Subtype of Breast Cancer in Defining the Cancer: Host Immunologic Interaction


N/A
18 Years
49 Years
Open (Enrolling)
Female
Breast Cancer, Breast Cancer and Pregnancy

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Trial Information

A Translational Study of the Interactions Between Prior Pregnancy and the Biologic Subtype of Breast Cancer in Defining the Cancer: Host Immunologic Interaction


The investigators will be looking at the level of immune suppression in different types of
breast cancer. The investigators will use blood, urine, and tissue samples from patients
with Pregnancy Associated Breast Cancer (PABC) versus non-PABC, as well as comparing
different types of breast cancer. If tissue sampling permits, the investigators may use
some of the breast cancer tissue to develop models for human cancer for drug targeting.
Understanding the immune response and suppression in different types of cancer will help us
understand mechanisms involved in breast cancer better and help the investigators in
developing new treatment in the future.


Inclusion Criteria:



- Females 50 or younger

- Histological or cytological confirmation of breast cancer

- Any clinical stage is allowed

Exclusion Criteria:

- Any known autoimmune condition, chronic steroid use, underlying immune disease (other
than breast cancer), use of immunomodulatory prescription drugs for any medical
condition.

- The presence of other comorbid conditions known to impact immune function, (such as:
type I diabetes, uncontrolled adult onset diabetes, severe chronic obstructive
pulmonary disease (COPD), uncontrolled infection or known HIV infection.)

- Underlying psychiatric condition which would, in the opinion of the investigator,
preclude compliance with study requirements

- Diagnosed with another type of cancer within 5 years except for breast cancer,
cervical or non-melanomatous skin cancer.

Type of Study:

Observational

Study Design:

Time Perspective: Retrospective

Outcome Measure:

Progression Free Survival

Outcome Description:

Prospective cohort study.

Outcome Time Frame:

Throughout study participation

Safety Issue:

No

Principal Investigator

Virginia Borges, MD, MMSc

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Colorado, Denver

Authority:

United States: Institutional Review Board

Study ID:

09-0583.cc

NCT ID:

NCT01503190

Start Date:

July 2007

Completion Date:

July 2021

Related Keywords:

  • Breast Cancer
  • Breast Cancer and Pregnancy
  • Breast Cancer
  • Young Women
  • Pregnancy Associated Breast Cancer
  • Pregnancy
  • Premenopausal Breast Cancer
  • Breast Neoplasms

Name

Location

University of Colorado DenverDenver, Colorado  80262