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Effects of Different Inspiratory to Expiratory Ratios on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position


N/A
40 Years
80 Years
Not Enrolling
Both
Lung Cancer, Lung Lobectomy

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Trial Information

Effects of Different Inspiratory to Expiratory Ratios on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position


Increasing inspiratory time(e.g. Inverse ratio ventilation) has been known that had
advantage of alveolar recruitment, preventing of ateletasis. On the contrary, it has
disadvantange of intrinsic PEEP, air trapping. There is few study on one lung ventilation in
lateral decubitus position about this ventilation method. We were going to investigate
effecf of this ventilation method.


Inclusion Criteria:



- ASA physical status class I, II

- Use of Double lumen tube

- Unilateral lung lobectomy

Exclusion Criteria:

- COPD

- CAOD

- Unstable hemodynamic status

- Peak airway pressure > 30mmHg (Two lung ventilation)

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

intrapulmonary shunt fraction

Outcome Description:

T1,T2,T3,T4 : ALL mesurement in lateral decubitus position T1-intrapulmonary shunt T2-intrapulmonary shunt T3-intrapulmonary shunt T4-intrapulmonary shunt

Outcome Time Frame:

T1 (10min before one lung ventibation)T2 (30min after one lung ventilation started)T3 (60min after one lung ventilation started)T4 (10min after two lung ventilation)

Safety Issue:

Yes

Principal Investigator

Young Jun Oh, MD,PhD

Investigator Role:

Study Chair

Investigator Affiliation:

Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea

Authority:

South Korea:Korea food and Drug Administration

Study ID:

1-2011-0058

NCT ID:

NCT01499212

Start Date:

July 2011

Completion Date:

December 2011

Related Keywords:

  • Lung Cancer
  • Lung Lobectomy
  • Lung Neoplasms

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