Inclusion Criteria:

- Metastatic or unresectable stage IIIc & clearly progressive melanoma

- Melanoma must be documented to contain a BRAFV600 mutation

- Measurable disease

- No more than 2 prior systemic treatment regimens for distant metastatic disease. The
following prior therapy is permitted in either the adjuvant or metastatic setting:
immunotherapy consisting of interferon, interleukin-2, GM-CSF, ipilimumab, anti-PD1
or other experimental agent; and cytotoxic chemotherapy consisting of dacarbazine,
temozolomide, carboplatin +/- paclitaxel

- ECOG performance status of 0, 1, or 2

Exclusion Criteria:

- Pregnant or nursing mothers

- Treatment with a prior VEGF pathway, BRAF, or MEK inhibitor(s)

- Receipt of any other investigational agents during the period on study or the four
weeks prior to entry

- Clinical evidence of active brain metastasis

- Concurrent uncontrolled malignancies that require therapy or other intervention

- Major surgical procedure, open biopsy (excluding skin cancer resection), or
significant traumatic injury within 28 days prior to Day 1 or anticipation of need
for major surgical procedure during the course of the study

- Core biopsy, skin cancer resection, or other minor surgical procedure within 7 days
prior to Day 1 of the protocol

- Serious intercurrent illness

- HIV-positive patients receiving combination anti-retroviral therapy