A Phase II Study of Concurrent Nab-Paclitaxel, Carboplatin and Thoracic Radiotherapy in Local Advanced Squamous Cell Lung Cancer
This study was conducted to explore the efficacy and toxicity of concurrent
chemoradiotherapy with nab-paclitaxel, carboplatin and thoracic radiotherapy in unresectable
local advanced squamous cell lung cancer. Patients will be given nab-paclitaxel weekly at a
dose of 60mg/m2, in combination with carboplatin (AUC 2) weekly during concurrent
chemoradiotherapy. Thoracic radiation was administered at a dose of 66 Gy/33 fractions, both
3 dimensional conformal and intensity modulated radiation therapy are allowed. Two cycles of
consolidation therapy with full dose nab-paclitaxel (260 mg/m2 on day 1) and carboplatin
(AUC 6 on day 1) every 21 day will be delivered.
Interventional
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
tumor response rate
one month after the end of all treatment
Yes
Shenglin Ma, MD
Principal Investigator
The First People's Hospital of Hangzhou
China: Ethics Committee
HZFH CA11-01
NCT01494415
January 2012
June 2014
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