Inclusion Criteria:

1. Patients should have advanced or metastatic RCC confirmed by histological diagnosis

2. Patients considered suitable for therapy with TKI for RCC according to responsible
clinician

3. Measurable tumour according to RECIST v1.1 criteria

4. Standard staging CT scan performed within 28 days of first research scan

5. The patient has not received chemotherapy, radiotherapy, surgery or any other
treatment against cancer within 4 weeks prior to recruitment

6. Age ≥18 years

7. Adequate renal function (creatinine <1.25xULN)

8. Patient is able to tolerate and comply with scanning procedure

9. Patient is not lactating or pregnant

10. Absence of any psychological, familial, sociological or geographical condition which
in the opinion of the Investigator may potentially hamper compliance with the study
protocol and follow-up schedule; those conditions should be discussed with the
patient before registration in the trial

11. Able and willing to give informed consent

Exclusion Criteria:

- Not applicable