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Notch Signaling and Novel Biomarkers for Barretts Esophagus


N/A
18 Years
N/A
Open (Enrolling)
Both
Barrett's Esophagus

Thank you

Trial Information

Notch Signaling and Novel Biomarkers for Barretts Esophagus


This research study hopes to identify new molecular markers in the tissue of Barrett's
esophagus that will help physicians better understand and manage this condition. Currently
there is very little understanding as to how Barrett's esophagus develops and why some
people with Barrett's esophagus go on to develop esophageal cancer. The purpose of this
study is to develop a better understanding of how these processes occur. The investigators
also hope to use the information from this study to identify new molecular markers that the
investigators can use to better determine who will or will not go on to develop esophageal
cancer. Patients who have been diagnosed in the past with Barrett's esophagus will be asked
to participate. Patients without Barrett's esophagus will be asked to take part so that the
investigators can compare tissue from patients without the conditions to those with the
conditions.


Inclusion Criteria:



For BE patients:

- History of histologically confirmed BE, defined as endoscopically-suspected BE with
intestinal metaplasia with globlet cells on esophageal biopsies,

- BE length C1M1 or C0M2

- Age 18 years

Exclusion Criteria:

- History of gastric or esophageal surgery

- Inability to give informed consent

- Erosive esophagitis seen on upper endoscopy

- History of prior endoscopic therapy for BE 5 (for controls) History of intestinal
metaplasia on previous esophageal, GE junction or cardia biopsies.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Gary Falk, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Abramson Cancer Center of the University of Pennsylvania

Authority:

United States: Institutional Review Board

Study ID:

UPCC 22211

NCT ID:

NCT01484925

Start Date:

November 2011

Completion Date:

November 2013

Related Keywords:

  • Barrett's Esophagus
  • Barrett's esophagus
  • Barrett Esophagus

Name

Location

Abramson Cancer CenterPhiladelphia, Pennsylvania  19104