Inclusion Criteria

Population:

All patients already scheduled for biopsy because of a raised Prostate-Specific Antigen
(PSA) and/ or abnormal Digital Rectal Examination (DRE) in the Academic Medical Centre
(AMC), excluding patients who do meet the exclusion criteria.

Inclusion criteria:

- age ≥ 18 years

- signed informed consent

Exclusion criteria:

- Has documented acute prostatitis or urinary tract infections.

- History of any clinically unstable cardiac condition including class III/IV cardiac
failure or right-to-left shunts.

- Has had severe cardiac rhythm disorders within the last 7 days.

- Has severe pulmonary hypertension (pulmonary artery pressure >90 mmHg) or
uncontrolled systemic hypertension or respiratory distress syndrome

- Has received a biopsy procedure within 30 days before admission into this study

- Has any medical condition or other circumstances which would significantly decrease
the chances of obtaining reliable data, achieving study objectives, or completing the
study.

- Is incapable of understanding the language in which the information for the patient
is given.