Know Cancer

forgot password

Quantification of Contrast Enhanced Ultrasound (CEUS) in the Detection of Prostate Cancer

18 Years
Open (Enrolling)
Prostate Cancer

Thank you

Trial Information

Quantification of Contrast Enhanced Ultrasound (CEUS) in the Detection of Prostate Cancer

Inclusion Criteria


All patients already scheduled for biopsy because of a raised Prostate-Specific Antigen
(PSA) and/ or abnormal Digital Rectal Examination (DRE) in the Academic Medical Centre
(AMC), excluding patients who do meet the exclusion criteria.

Inclusion criteria:

- age ≥ 18 years

- signed informed consent

Exclusion criteria:

- Has documented acute prostatitis or urinary tract infections.

- History of any clinically unstable cardiac condition including class III/IV cardiac
failure or right-to-left shunts.

- Has had severe cardiac rhythm disorders within the last 7 days.

- Has severe pulmonary hypertension (pulmonary artery pressure >90 mmHg) or
uncontrolled systemic hypertension or respiratory distress syndrome

- Has received a biopsy procedure within 30 days before admission into this study

- Has any medical condition or other circumstances which would significantly decrease
the chances of obtaining reliable data, achieving study objectives, or completing the

- Is incapable of understanding the language in which the information for the patient
is given.

Type of Study:


Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Quantification prediction compared with prostate biopsy histology

Outcome Description:

Prostate cancer detection rate by quantification. Answering the question: What is the difference in, for malignancy suspicious, areas between CEUS quantification and subjective interpretation in relation to the histological biopsy results?

Outcome Time Frame:

3 years

Safety Issue:


Principal Investigator

H. Wijkstra, Prof. Dr. Ir.

Investigator Role:

Principal Investigator

Investigator Affiliation:

AMC University Hospital


Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:




Start Date:

November 2011

Completion Date:

November 2015

Related Keywords:

  • Prostate Cancer
  • Contrast Enhanced Ultrasound (CEUS)
  • Prostate cancer
  • Quantification
  • Prostate biopsies
  • Transrectal ultrasound (TRUS)
  • Microbubbles
  • Prostatic Neoplasms