Inclusion Criteria:

- Metastatic Colorectal Carcinoma with KRAS mutation.

- Received first line therapy and discontinued part or all of first line therapy.

- Estimated life expectancy > 3 months.

- Stage IV disease.

- ECOG 0-2.

- Adequate hepatic and hematologic function

- No major operations within 4 weeks prior to treatment start.

Exclusion Criteria:

- More than 1 prior chemotherapy regimen for stage 4 colorectal cancer.

- Experimental medical treatment within 30 days prior to study entry.

- Known or suspected cerebral metastases.

- History or presence of any form of cancer, other that colorectal cancer, within the 3
years prior to enrollment.

- Known dihydropyrimidine dehydrogenase-deficiency (special screening not required).

- Subjects with angina pectoris, poorly controlled ventricular arrhythmias (does not
include asymptomatic, occasional premature ventricular contractions), history of
clinically significant coronary heart disease or cardiomyopathy, or ECG abnormalities
consistent with ischemia.

- Uncontrolled hypertension (seated systolic blood pressure > 180 mmHg or diastolic
blood pressure > 110 mmHg) at Screening.

- Clinically active liver disease, including active hepatitis (any etiology) or
cirrhosis.

- Anti-tumor therapy (chemotherapy, antibody therapy, molecular targeted therapy,
retinoid therapy, hormonal therapy) within 21 days prior to randomization

- Prior irinotecan therapy for metastatic disease is not permitted.

- Systemic fungal, bacterial, viral, or other infection.