Inclusion Criteria:

- Adult patients, >/=18 years of age

- Diagnosis of recurrent glioblastoma multiforme (Grade IV)

- Previous treatment with temozolomide and radiotherapy

- First recurrence after standard adjuvant treatment (surgery, followed by radiotherapy
and chemotherapy)

- Adequate hematological, biochemical and organ functions

Exclusion Criteria:

- Previous treatment with Avastin or other anti-angiogenic drugs

- Residual relevant toxicity resulting from previous therapy

- Radiotherapy within the 3 months prior to the diagnosis of disease progression

- Chemotherapy in the previous 4 weeks

- Other active or inactive malignancies (except for carcinoma in situ of the cervix, of
the prostate or basal cell carcinoma)

- Clinically significant cardiovascular diseases