Oral Contraceptives and Subantimicrobial Doxycycline: Effect on Endometrial MMPs
Continuous oral contraceptive administration entails women taking hormonally active pills
for 28 days without a seven day placebo week to avoid hormonal withdrawal bleeding.
Unfortunately, with continuous administration, timed, regular bleeding can be replace by
irregular, unscheduled bleeding, which often leads to dissatisfaction, discontinuation and
the possibility of unplanned pregnancy.
MMPs, a group of zinc-dependant proteases, are hypothesized to play a role in endometrial
degradation. The purpose of this study is to describe the expression of MMPs in endometrial
biopsy (EMB) specimens collected 1) prior to initiating oral contraceptives 2) while taking
cyclic oral contraceptive 3) while taking continuous oral contraceptives and 4) while taking
continuous oral contraceptives along with sub-antimicrobial doxycycline.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Determine the effect of combined oral contraceptives on endometrial MMP expression.
Baseline MMP expression will be determined on day 19-21 of cycle 1. During cycle 2, when women are taking the cyclic oral contraceptive, the EMB will be performed between cycle day 19-21 (study day 47-49), prior to endometrial degradation.
Bliss Kaneshiro, MD, MPH
University of Hawaii John A. Burns School of Medicine Department of Obstetrics and Gynecology
United States: Federal Government
UH DOXY RTRN
|Kapiolani Medical Center for Women and Children||Honolulu, Hawaii 96826|