Inclusion Criteria:

1. Having signed informed consent

2. Age≥ 18 years old

3. Histologically confirmed gastric adenocarcinoma

4. Unresectable recurrent or metastatic disease

5. Previous neo-adjuvant or adjuvant treatment for gastric cancer, if applicable, more
than 6 months

6. Previous chemotherapy with oxaliplatin or cisplatin or paclitaxel or docetaxel, if
applicable, more than 12 months.

7. Measurable disease according to the RECIST criteria

8. ECOG performance status ≤2

9. Life expectancy of ≥3 month

10. No prior radiotherapy except radiotherapy at non-target lesion of the study more than
4 weeks

11. ALT and AST≤2.5 times ULN (≤5 times ULN in patients with liver metastases) Serum
albumin level ≥3.0g/dL Serum creatinine ≤1.5ULN Bilirubin level ≤ 1.5 ULN
WBC>3,000/mm3, absolute neutrophil count ≥1500/mm3, platelet>90,000/mm3, Hb>8g/dl

Exclusion Criteria:

1. Brain metastasis (known or suspected)

2. Previous systemic therapy for metastatic gastric cancer

3. Inability to take oral medication

4. Previous therapy targeting at angiogenesis or vasculogenesis pathway or other
targeted therapy

5. Surgery (excluding diagnostic biopsy) within 4 weeks prior to study entry

6. Allergic constitution or allergic history to any investigating agents.

7. Severe heart disease or such history as recorded congestive heart failure,
uncontrolled cardiac arrhythmia, angina pectoris needing medication, cardiac valve
disease, severe abnormal ECG findings, cardiac infarction , or retractable
hypertension.

8. Pregnancy or lactation period

9. Any investigational agent within the past 28 days

10. Other previous malignancy within 5 year

11. Pre-existing neuropathy>grade 1

12. Legal incapacity