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Detection of DNA Mutations in Head and Neck Squamous Cell Carcinoma


N/A
18 Years
N/A
Not Enrolling
Both
Head and Neck Cancer

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Trial Information

Detection of DNA Mutations in Head and Neck Squamous Cell Carcinoma


OBJECTIVES:

- To determine the mutation rates of HRAS and PIK3CA in patients with head and neck
squamous cell carcinoma (HNSCC) who were treated with cisplatin/placebo and
cisplatin/cetuximab on protocol ECOG-E5397.

- To determine the association between HRAS or PIK3CA mutation status and clinical
benefits (i.e., response, progression-free survival, and overall survival) in patients
treated with cisplatin/cetuximab compared with those receiving cisplatin/placebo on
protocol ECOG-E5397.

OUTLINE: DNA is isolated from one unstained slide per patient. The mutations in HRAS and
PIK3CA are determined using BEAMING technology.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Treated on protocol ECOG-E5397

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Mutation rates of HRAS and PIK3CA

Safety Issue:

No

Principal Investigator

Christine H. Chung, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Sidney Kimmel Comprehensive Cancer Center

Authority:

Unspecified

Study ID:

CDR0000715520

NCT ID:

NCT01466257

Start Date:

December 2011

Completion Date:

Related Keywords:

  • Head and Neck Cancer
  • metastatic squamous neck cancer with occult primary squamous cell carcinoma
  • recurrent metastatic squamous neck cancer with occult primary
  • recurrent squamous cell carcinoma of the hypopharynx
  • recurrent squamous cell carcinoma of the larynx
  • recurrent squamous cell carcinoma of the lip and oral cavity
  • recurrent squamous cell carcinoma of the oropharynx
  • recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage III squamous cell carcinoma of the hypopharynx
  • stage III squamous cell carcinoma of the larynx
  • stage III squamous cell carcinoma of the lip and oral cavity
  • stage III squamous cell carcinoma of the oropharynx
  • stage III squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage IV squamous cell carcinoma of the hypopharynx
  • stage IVA squamous cell carcinoma of the larynx
  • stage IVA squamous cell carcinoma of the lip and oral cavity
  • stage IVA squamous cell carcinoma of the oropharynx
  • stage IVA squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage IVB squamous cell carcinoma of the larynx
  • stage IVB squamous cell carcinoma of the lip and oral cavity
  • stage IVB squamous cell carcinoma of the oropharynx
  • stage IVB squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage IVC squamous cell carcinoma of the larynx
  • stage IVC squamous cell carcinoma of the lip and oral cavity
  • stage IVC squamous cell carcinoma of the oropharynx
  • stage IVC squamous cell carcinoma of the paranasal sinus and nasal cavity
  • untreated metastatic squamous neck cancer with occult primary
  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms

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