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Comparison of [F-18] FDG Positron Emission Tomography and Multinuclear (31P and 1H) Magnetic Resonance Spectroscopy as Complementary Bioenergetic Imaging Modalities in Healthy Human Brain and Major Depressive Disorder


N/A
18 Years
55 Years
Open (Enrolling)
Both
Major Depressive Disorder

Thank you

Trial Information

Comparison of [F-18] FDG Positron Emission Tomography and Multinuclear (31P and 1H) Magnetic Resonance Spectroscopy as Complementary Bioenergetic Imaging Modalities in Healthy Human Brain and Major Depressive Disorder


Inclusion Criteria:



- Meet DSM-IV TR criteria for MDD, Recurrent

- Montgomery-Asberg Depression Rating Scale (MADRS) score > 18

Exclusion Criteria:

- Any coexisting psychiatric illness other than generalized anxiety disorder, panic
disorder, or social/specific phobias

- Any history of substance dependence

- Substance abuse within the past 6 months

- Significant risk of suicide, as defined by score >4 on item 10 of the MADRS or in the
clinical judgment of the study physician

- Any significant medical or neurological condition which is likely to impact the
central nervous system and/or affect the results of MRS or PET imaging

- For the subset of unmedicated MDD patients, any psychotropic medications within 4
weeks prior to scanning. For the subgroup of medicated patients, they may be taking
a stable dose (i.e., same dose for at least 4 weeks at the time of scanning) of
standard antidepressant medications, but may not be taking any other psychotropic
medication.

- Inability to give informed consent

- Contraindication to MRI (e.g., pacemaker, ferromagnetic implants in the body)

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Outcome Measure:

high energy phophate metabolites (i.e., ANP and PCr) as measured by magnetic resonance spectroscopy

Outcome Time Frame:

cross-sectional

Safety Issue:

No

Principal Investigator

Paul J Carlson, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Utah

Authority:

United States: Food and Drug Administration

Study ID:

WIBR08-PJC

NCT ID:

NCT01465165

Start Date:

June 2009

Completion Date:

May 2012

Related Keywords:

  • Major Depressive Disorder
  • Depression
  • Positron emission tomography
  • Magnetic resonance spectroscopy
  • glucose metabolism
  • ATP
  • phosphocreatine
  • Depressive Disorder
  • Depression
  • Depressive Disorder, Major

Name

Location

University of Utah Dept of PsychiatrySalt Lake City, Utah  84112