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Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia

18 Years
Open (Enrolling)
Chronic Lymphocytic Leukemia

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Trial Information

Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia

The investigators plan to use a novel antibody developed at Dartmouth-Hitchcock Medical
Center to characterize the expression of LPL in CLL. Peripheral blood from CLL patients will
be analyzed by flow cytometry to detect the expression of LPL and to investigate if LPL
expression correlates with a more aggressive type of CLL. The investigators propose that LPL
protein expression on CLL cells is prognostic and that LPL and other proteins involved in
fatty acid metabolism are critical for CLL cells to survive.

Inclusion Criteria:

- Diagnosis of CLL as per National Cancer Institute Working Group Guidelines

- Patients undergoing routine blood draws as part of their ongoing follow up for CLL

- 18 years or older

- Ability to provide consent in English

- Patient must have measurable disease as defined by an absolute lymphocyte count
greater than 5,000/mm3 or have archived lymph node or bone marrow with CLL

Exclusion Criteria:

- Patients who have received cytotoxic drug, oral or intravenous steroid or targeted
antibody therapy for their CLL,

- other hematologic malignancy or other disease process within the past 6 months are

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

LPL Protein Expression

Outcome Description:

Determine the degree of LPL protein expression in CLL cells using a novel LPL antibody, correlate with IgHV mutation status, and compare this association with other prognostic markers

Outcome Time Frame:

1 year

Safety Issue:


Principal Investigator

Frederick Lansigan, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dartmouth-Hitchcock Medical Center


United States: Institutional Review Board

Study ID:




Start Date:

October 2011

Completion Date:

December 2014

Related Keywords:

  • Chronic Lymphocytic Leukemia
  • Lipoprotein Lipase
  • Chronic Lymphocytic Leukemia
  • CLL
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid



Dartmouth-Hitchcock Medical CenterLebanon, New Hampshire  03756