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Whole Body Functional and Anatomical MRI: Accuracy in Staging and Treatment Response Monitoring in Adolescent Hodgkin's Lymphoma Compared to Conventional Multimodality Imaging


N/A
6 Years
18 Years
Open (Enrolling)
Both
Lymphoma, Hodgkin

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Trial Information

Whole Body Functional and Anatomical MRI: Accuracy in Staging and Treatment Response Monitoring in Adolescent Hodgkin's Lymphoma Compared to Conventional Multimodality Imaging


The trial will be a single centre cohort study in patients newly diagnosed with Hodgkin's
lymphoma undergoing disease staging at diagnosis and initial treatment response assessment.
At each time point (initial staging and treatment response assessment) in addition to
standard imaging investigations (PET CT, Chest CT, anatomical MRI of the abdomen and pelvis
and abdominal USS), patients will undergo advanced anatomical and functional MRI sequences.


Inclusion Criteria:



- Aged 6 to 18 years (inclusive) with participant and parent/guardian informed consent

- Histologically confirmed first presentation of Hodgkin's Lymphoma

- Either entered into the Euronet PHL-C1 trial or LP1 trials OR not formally entered
into the Euronet trials but treated on the chemotherapy regimens of the Euronet
trials for classical and lymphocyte predominant Hodgkin Lymphoma

Exclusion Criteria:

- Contraindications to MRI (e.g. pacemaker)

- Previous malignancy or previous chemotherapy or radiotherapy treatment for malignancy

- Pregnancy or nursing

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

The per site sensitivity and specificity of MRI for both nodal and extranodal sites and concordance in final disease stage with the multi-modality reference standard

Outcome Time Frame:

The recruited patients to be followed up for 1 year

Safety Issue:

No

Principal Investigator

Stuart A Taylor, Prof

Investigator Role:

Principal Investigator

Investigator Affiliation:

UCLH

Authority:

United Kingdom: Research Ethics Committee

Study ID:

UCL10/0271

NCT ID:

NCT01459224

Start Date:

September 2011

Completion Date:

March 2015

Related Keywords:

  • Lymphoma, Hodgkin
  • Hodgkin Disease
  • Lymphoma

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