Inclusion Criteria:

- mantle cell Lymphoma CD20 positive

- Untreated patients

- 65 ans years old patients or 18 to 65 years old patients who can't or refuse receive
conditioning regimen followed by autograft.

- Stages Ann Arbor II, III or IV,

- ECOG performance status of 0, 1 or 2

- Without history of neoplasm, except in situ cervix carcinoma and cutaneous basal cell
epithelioma, or in complete remission since 3 years,

- Without drug contraindication used in the schema (Rituximab, benda-mustine,
Velcade, Dexamethasone),

- Without heart insufficiency or stabilized,

- With the following biological values limits except if pathological values are due to
Medullary invading or hypersplenism, hepatic involvement) :PNN more than 1 G/L,
Platelets more than 50 G/L,Transaminases (SGOT and SGPT) and alkalin phosphatases
alcalines less than 4 x normal,Bilirubin less than 3 x N,- Clearance creatinemia more
than 20 mL/min

- Hepatitis B negative serology unless the seropositivity is clearly linked to a
vaccination.

- Can be regularly followed

- Who signed the informed consent,

- Affiliated to a national insurance or such a same scheme .

Exclusion Criteria:

- Other type of lymphoma than mantle cell lymphoma according to OMS 2008 classification

- Patients in relapse, except those in relapse due to localized stade who only received
locoregional irradiation or splenectomized,

- Central nervous system localization in particular meninge,

- Drug used in the schema contraindication Rituximab , Bendamustine , Velcade® or
Dexamethasone

- Non stable diabetes,

- HIV positive or active hepatitis C or B

- ECOG performance status equal or more than 3

- Peripheral neuropathy, whatever its origin, rated more than 2 from NCI

- Non stabilized heart insufficiency,

- Patient who can't receive hyperhydration in order to treat tumoral lysis syndrome or
in prophylaxis,

- Patient who can't, whatever the reason, be regularly followed,

- Major patient who are on legal protection, or can't give their consent

- Patient who has not signed the informed consent