Inclusion Criteria:

- Patients with histologic diagnosis of adenocarcinoma of the upper gastrointestinal
tract, including patients with any of the following diagnoses and settings who are
candidates to receive radiation which concurrent continuous infusion 5-FU
chemotherapy: Pancreatic adenocarcinoma (unresected and adjuvant), Duodenal
adenocarcinoma (unresected or adjuvant), Cholangiocarcinoma (unresected or adjuvant),
Gastric adenocarcinoma (unresected or adjuvant), Gastroesophageal junction adeno
carcinoma (adjuvant)

- Patient must be >18 years of age.

- Patient must have an ECOG Performance Status of 0-2, and a life expectancy of greater
than or equal to 3 months.

- Patient must be able to provide informed consent.

- Women of child-bearing potential as long as she agrees to use a recognized method of
birth control (e.g. oral contraceptive, IUD, condoms or other barrier methods etc.).
Hysterectomy or menopause must be clinically documented.

Exclusion Criteria:

- Prior or simultaneous malignancies within the past two years (other than cutaneous
squamous or basal cell carcinoma, melanoma in situ or thyroid carcinoma)

- Pregnant women, women planning to become pregnant and women that are nursing.

- Patients who experience surgical complications which prevent radiation from starting
for 3 months or more.