Prevention of Postoperative Pneumonia (POPP Study: A Study to Evaluate the Use of a Prophylactic Clinical Strategy to Prevent Postoperative Pneumonia in Patients Undergoing Thoracic Surgery
1. Patients with lung lesions undergoing anatomic resection
(lobectomy/segmentectomy/bilobectomy/pulmonary sleeve resection/pneumonectomy)
2. Patients with poor lung function (FEV1% <50% or DLCO<50% predicted or home oxygen
requirement) and lung lesions undergoing non-anatomic lung resection (i.e. wedge
3. Patients undergoing esophageal resection.
1. Patients with ongoing symptomatic dental infections.
2. Patients with recent/ongoing pneumonia (<15 days from initial surgical patient
3. Patients who've received a therapeutic course of antibiotics within 15 days prior to
4. Patients with a preexisting tracheostomy.
Type of Study:
Allocation: Randomized, Masking: Open Label, Primary Purpose: Prevention
Incidence of postoperative pneumonia in the two groups: lung cancer resection patients and esophageal resection patients
Patients will be considered to have postoperative pneumonia if they meet three of the following criteria within 30 days after surgery;
Fever (Temperature >38.2 C)
Leucocytosis (WBC>12,000/cu mm)
New infiltrate on chest X-ray
Positive sputum or bronchial culture
Treatment with antibiotics These criteria are utilized by the national Society of Thoracic Surgeons' database.
United States: Institutional Review Board
- Post-operative Pneumonia
- Lung Cancer
- Esophageal Cancer
- Incidence of post-operative pneumonia in patients undergoing surgery for primary lung cancer or primary esophageal cancer
- Esophageal Diseases
- Esophageal Neoplasms
- Lung Neoplasms
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||Saint Louis, Missouri 63110