Inclusion Criteria

- INCLUSION CRITERIA:

- Patients with histologically documented solid tumors or lymphoid malignancies
(lymphoma and CLL) refractory to standard therapy or who have no acceptable standard
treatment options. Patients with lymphoid malignancies will be eligible if their
disease has progressed following standard therapy and if stem cell transplantation is
not indicated or has been refused.

- Any prior therapy must have been completed greater than or equal to 4 weeks (greater
than 6 weeks for nitrosoureas or mitomycin C) prior to enrollment on protocol, and
the participant must have recovered to eligibility levels (CTCAE Grade less than or
equal to 1) from prior toxicity. Prior radiation should have been completed greater
than or equal to 4 weeks prior to study enrollment, and all associated toxicities
should have resolved to eligibility levels. Patients must be greater than or equal to
2 weeks since any investigational agent administered as part of a Phase 0 study, and
should have recovered to eligibility levels from any toxicities.

- Age greater than or equal to 18 years. Because no dosing or adverse event data are
currently available on the use of ABT-888 in patients less than 18 years of age,
children are excluded from this study, but may be eligible for future pediatric Phase
I combination trials.

- Karnofsky performance status greater than or equal to 60%, see Appendix A.

- Life expectancy of greater than 3 months.

- Patients must have normal organ and marrow function as defined below:

- absolute neutrophil count greater than or equal to 1,500/microL (mcL)

- platelets greater than or equal to 100,000/microL (mcL)

- total bilirubin less than 1.5 times the institutional upper limit of normal

- AST(SGOT)/ALT(SGPT) less than or equal to 2.5 times the institutional upper
limit of normal

- creatinine less than 1.5 times the institutional upper limit of normal

OR

creatinine clearance greater than or equal to 60 mL/min for patients with creatinine
levels 1.5 times the institutional upper limit of normal.

- The effects of ABT-888 on the developing human fetus are unknown. For this reason and
because cyclophosphamide hydrochloride used in this trial is known to be teratogenic,
women of childbearing potential and men must agree to use adequate contraception
(abstinence; female use of hormonal methods, or barrier methods of birth control;
male use of a condom) prior to study entry, for the duration of study participation,
and for 3 months after completion of study. Because there is a risk for adverse
events in nursing infants secondary to treatment of the mother with cyclophosphamide,
breastfeeding should be discontinued while the patient is on this trial and for 30
days after completion of treatment on this trial. Should a woman become pregnant or
suspect she is pregnant while participating in this study, she should inform her
treating physician immediately.

- Ability to understand and the willingness to sign a written informed consent
document.

EXCLUSION CRITERIA:

- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for
nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered
from adverse events due to agents administered more than 4 weeks earlier. Patients must be
greater than or equal to 2 weeks since any investigational agent administered as part of a
Phase 0 study, and should have recovered to eligibility levels from any toxicities.

Patients who have been administered ABT-888 as part of a single or limited dosing study,
such as a Phase 0 study, should not be excluded from participating in this study solely
because of receiving prior ABT-888.

Patients who have received prior cyclophosphamide should not be excluded solely because of
receiving prior cyclophosphamide.

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.

- Patients with gliomas, symptomatic CNS metastases or carcinomatous meningitis are
excluded from this clinical trial. Patients with history of CNS metastases who have
received treatment and whose CNS metastatic disease status has remained stable for
greater than or equal to 3 months without steroids or anti-seizure medications may be
eligible. These patients may be enrolled at the discretion of the principal
investigator.

- Patients with a history of seizures.

- Patients with HIV who are taking protease inhibitors.

- Patients with gastrointestinal conditions that might predispose for drug
intolerability or poor drug absorption (e.g., inability to take oral medication or a
requirement for IV alimentation, prior surgical procedures affecting absorption,
malabsorption syndrome, active peptic ulcer disease) are excluded. Subjects with
ulcerative colitis, inflammatory bowel disease, or a partial or complete small bowel
obstruction are also excluded.