Inclusion Criteria

- INCLUSION CRITERIA:

Patients must have breast and/or epithelial ovarian cancer, primary peritoneal cancer,
and/or fallopian tube cancer histologically or cytologically confirmed at the NCI that is
metastatic or unresectable and for which standard curative measures do not exist or are no

longer effective.

All patients in cohort 1 must have measurable and/or evaluable disease.

Patients in the expansion cohort 2 must have safely biopsible disease as determine by an
interventional radiologist and must agree to the first mandatory biopsy (the other two
biopsies optional).

Breast cancer patients with locally advanced, unresectable disease must have been
previously treated with standard therapy.

There is no limit on number of prior therapy.

Patients must be at least 6 months from their last platinum exposure.

Platinum-resistant patients may participate.

Patients with allergic reaction to platinums (up to and including grade 3 without a
reaction protocol, and up to and including grade 2 in the face of pretrement, but not
graduated treatment exposure) are still eligible.

Age greater than or equal to 18 years.

ECOG performance status less than or equal to 2 (Karnofsky greater than or equal to 60%).

Life expectancy greater than 3 months.

Patients must have normal organ and marrow function as defined below:

- hemoglobin greater than or equal to 10g/dL

- leukocytesgreater than or equal to 3,000/mcL

- absolute neutrophil count greater than or equal to 1,500/mcL

- platelets greater than or equal to 100,000/mcL

- total bilirubin less than or equal to upper limit of normal (ULN) in the absence of
Gilbert's syndrome

- AST(SGOT)/ALT(SGPT) less than or equal to 2.5 X ULN

- creatinine clearance greater than or equal to 60 mL/min by 24-hour urine

OR

- serum creatinine less than or equal to 1.5 mg/dl

- corrected or Ionized Calcium less than or equal to ULN

- potassium within normal limits

A documented deleterious BRCA 1/2 germline mutation or BRCAPRO score of greater than or
equal to 30% for patients enrolling in Group A.

For patients enrolling in the sporadic serous epithelial ovarian cancer group, Group B, a
negative family history (BRCAPRO score less than or equal to 20% or negative BRCA1/2
mutation test).

For patients enrolling in the triple negative breast cancer (ER-/PR- /Her2-) group, Group
B, a negative family history and /or BRCAPRO score less than or equal to 10% or negative
BRCA1/2 mutation test).

The effects of AZD on the developing human fetus are unknown. For this reason and because
platinum agents are known to be teratogenic, men and women of child-bearing potential must
agree to use adequate contraception (hormonal or barrier method of birth control;
abstinence) prior to study entry and for the duration of study participation. Should a
woman become pregnant or suspect she is pregnant while participating in this study, she
should inform her treating physician immediately, Patients of child-bearing potential
should continue on contraception for at least three months following the last dose of
therapy on study.

Toxicities from previous cancer therapies must have recovered to grade 1 (defined by CTC
3.0). Chronic stable grade 2 peripheral neuropathy secondary to neurotoxicity from prior
therapies may be considered on a case by case basis by the Principal Investigator. No
patients with functional impairment due to neuropathy will be eligible for the study.
Hypomagnesemia will not be considered an exclusion criteria. Magnesium levels will be
monitored and replaced as clinically indicated. Ability to understand and the willingness
to sign a written informed consent document.

Female patients with reproductive potential must have a negative urine or serum pregnancy
test within 4 days prior to the start of the study.

EXCLUSION CRITERIA:

Patients who have had chemotherapy, biological therapy, hormonal therapy (with the
exception of raloxifene or others approved for bone health) or radiotherapy within 4 weeks
(6 weeks for nitrosoureas or mitomycin C) prior to entering the study.

Patients may not be receiving any other investigational agents or had them in the previous
28 days.

Patients with known brain metastases diagnosed within 1 year should be excluded from this
clinical trail because of their poor prognosis and because they often develop progressive
neurological dysfunction that would confound the evaluation of neurologic and other
adverse events.

---Patients with brain metastases diagnosed greater than 1 year prior to study entry are
eligible if they received sterilizing therapy to the CNS (resection or radiation) and have
been CNS recurrence-free for a full 1-year period.

Clinically significant bleeding.

Inability to swallow pills.

Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.

Pregnant and breast-feeding women.

HIV-positive patients on combination antiretroviral therapy are ineligible because of the
potential for pharmacokinetic interactions with AZD2281. In addition, these patients are
at increased risk of lethal infections when treated with marrow-suppressive therapy such
as carboplatin.

Previous treatment with PARP inhibitor.

Major surgery within the past 28 days.

Patients with locally advanced breast tumors presenting for their initial therapy, or
patients with local (only in breast or chest wall) recurrence only will not be eligible
for this trial

For subjects in the dose-expansion cohorts, history of prior invasive malignancies within
the past 5 years (with the exception of non-melanomatous skin cancers, non-invasive
bladder cancer, stage I endometrial cancer or cervical cancer cured by surgical
resection).

Patients with a history of grade 4 allergic reaction to platinums