Neoadjuvant Chemotherapy Versus Surgery Alone in Locally Advanced Gastric Cancer: A Randomized Controlled Study
Adenocarcinoma of the stomach ranks as the fourth most commonly diagnosed cancer and as the
second leading cause of cancer-related death in the world. Radical resection with
free-margin gastrectomy and extended lymphadenectomy is the preferred surgical strategy in
Japan and Asian centers.
Unfortunately, only one-half of surgically treated patients with gastric cancer will achieve
a complete resection without residual disease (R0) resection. Moreover, due to, the absence
of routine screening programs for gastric cancer, the majority of the patients will be
symptomatic at the time of diagnosis in our country.
Additionally, recent treatment strategies were focused for downsizing or decreasing to
In this reason, we hypothesize that preoperative chemotherapy may improve the R0 resection
rate or disease free and/or overall survival rate.
Observational Model: Case Control, Time Perspective: Prospective
After 2 years from therapy
Atilla Celik, M.D.
Haydarpasa Numune Teaching & Research Hospital, Affiliated by Ministery of Health of Turkey
Turkey: Ministry of Health