A Single Centre, Pilot Trial of YF476 in Patients With Chronic Atrophic Gastritis, Hypergastrinaemia and Type I Gastric Carcinoids
Inclusion Criteria:
- Patients known to have gastric carcinoids associated with chronic atrophic gastritis
and hypergastrinaemia, and who attend the outpatient clinic of the investigator;
- Men, postmenopausal women, premenopausal women who have been sterilised by tubal
ligation, hysterectomy or bilateral oophorectomy, or premenopausal women using
reliable contraception: condom and spermicide or intrauterine device;
- Adults ≥ 18 years;
- Good general health; and
- Able to give fully-informed, written consent.
Exclusion Criteria:
- Women who are pregnant, lactating or using a steroid contraceptive;
- History of gastric surgery, apart from surgery for gastric carcinoids;
- Evidence of Zollinger-Ellison syndrome;
- Prolonged QTc interval (>450 msec);
- Certain medicines and herbal remedies taken during the 7 days before visit 1;
- Previous treatment with somatostatin; or
- Participation in other clinical trials of unlicensed medicines within the previous 3
months.