Inclusion Criteria:

- Diagnosis of AML according to the WHO criteria

- Relapsed or refractory AML as defined below First relapse after standard treatment
with duration of the first remission less than year

- Refractoriness to an induction cycle that includes cytarabine and anthracyclines

- Nonpromyelocytic leukemia (absence of t(15;17) or PML-RARα rearrangement and its
variants)

- Peripheral blood blast cell count less than 50 x 109/L. Hydroxyurea and leukopheresis
can be used to lower the blast count prior to beginning treatment

- Age ≤ 65 years and ≥ 18 years

- ECOG performance status of 0-2

- Provide signed written informed consent

- Be able to comply with study procedures and follow-up examinations

- Be nonfertile or agree to use birth control during the study through the end of last
treatment visit

- Adequate renal and hepatic function as indicated by all of the following:

Total bilirubin <1.5 x Institutional Upper Limit of Normal (ULN); and AST and ALT <2.5
xULN; and Serum creatinine <1.0 mg/dL; if serum creatinine <1.0 mg/dL, then, the estimated
glomerular filtration rate (GFR) must be <60 ml/min/1.73 m2 as calculated by the
Modification of Diet in Renal Disease (MDRD) equation - Minimal impairment of cardiac
function as measured by at least 1 of the following: Left ventricular ejection fraction
(LVEF) >40% on multigated acquisition (MUGA) scan or radionuclide angiographic scan; or
Left ventricular fractional shortening >22% on echocardiography exam;

Exclusion Criteria:

- Diagnosis of acute promyelocytic leukemia (APL, French-American-British [FAB]
classification M3 or WHO classification of APL with t(15;17)(q22;q12), (PML/RARalfa
and variants)

- AML secondary to previous treatment for myelodysplastic syndrome (MDS)

- Peripheral blood blast cell count ≥ 50 x 109/L. Hydroxyurea and leukopheresis can be
used to lower the blast count prior to beginning treatment

- Prior investigational treatment within 30 days prior to the first dose of study drug.
If any investigational treatment has been received prior to this time point, drug
related toxicities must have recovered to Grade 1 or less prior to first dose of
study drug

- Prior hematopoietic stem cell transplant (HSCT) (previous autologous hematopoietic
stem cell transplant is allowed)

- Investigational agent received within 5 days prior to the first dose of study drug.
If received any investigational agent prior to this time point, drug-related
toxicities must have recovered to Grade 1 or less prior to first dose of study drug

- Impaired renal and liver function as indicated by the following:

Total bilirubin > 1.5 x upper limit of normal (ULN) provided that this is not attributable
to AML itself; or AST and ALT > 2.5 xULN provided that this is not attributable to AML
itself; or Serum creatinine > 1.0 mg/dL provided that the estimated glomerular filtration
rate (GFR) is ≤ 60 mL/min/1.73 m2 as calculated by the Modification of Diet in Renal
Disease (MDRD) equation

- Impaired cardiac function as measured by at least 1 of the following: Left ventricular
ejection fraction (LVEF) < 40% on multigated acquisition (MUGA) scan or radionuclide
angiographic scan; or Left ventricular fractional shortening < 22% on echocardiography
exam;

- Poor overall condition ECOG 3-4

- Refusal to sign the informed consent

- Unable to comply with study procedures and follow-up examinations

- Psychiatric disorders that could interfere with consent, study participation or
follow-up

- Systemic fungal, bacterial, viral, or other infection not controlled (defined as
exhibiting ongoing signs/symptoms related to the infection and without improvement,
despite appropriate antibiotics or other treatment)

- Diagnosis of another malignancy, unless the patient has been disease-free for at
least 5 years following the completion of curative intent therapy with the following
exceptions:

Patients with treated non-melanoma skin cancer, in situ carcinoma, or cervical
intraepithelial neoplasia, regardless of the disease-free duration, are eligible for this
study if definitive treatment for the condition has been completed Patients with
organ-confined prostate cancer with no evidence of recurrent or progressive disease based
on prostate-specific antigen (PSA) values are also eligible for this study if hormonal
therapy has been initiated or a radical prostatectomy has been performed

- Clinical evidence suggestive of central nervous system (CNS) involvement with
leukemia unless a lumbar puncture confirms the absence of leukemic blasts in the
cerebrospinal fluid (CSF)

- Prior positive test for the human immunodeficiency virus (HIV)

- History of hypersensitivity to any of the study drugs