Identifying Stat3-Dependent Chemotherapy Resistance Pathways in Relapsed AML
- Investigate whether changes in prosurvival signaling occur by comparing activation of
the signal transducer and activator of transcription-3 (Stat3) and Stat5 pathways in
paired diagnostic and relapse samples.
- Investigate changes in leukemia cell responses to extrinsic cues from the environment
change, using a bone marrow stromal-cell co-culture model of chemotherapy resistance.
OUTLINE: Cryopreserved samples are analyzed for Stat3 and Stat5 expression by flow cytometry
and in vitro chemotherapy sensitivity.
Changes in Stat3 and Stat5 in paired diagnostic and relapsed AML samples
Michele S. Redell, MD, PhD
Texas Children's Cancer Center
United States: Federal Government