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Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)


N/A
18 Years
N/A
Open (Enrolling)
Both
Lung Cancer

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Trial Information

Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)


OBJECTIVES:

- To identify and characterize single nucleotide variations (SNVs) in non-small cell lung
cancer (NSCLC) specimens.

- To identify and characterize structural variations in the genomes of NSCLC specimens.

- To identify and characterize other genomic alterations including, but not limited to,
expression profiling and methylation.

OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide
variations, structural variations in the genomes, and other genomic alterations including,
but not limited to, gene expression profiling and methylation. Clinical data related to
disease, treatment, and recurrence from each patient sample is also collected.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Registration to CALGB-140202

- Patient's tumor histology must be either primary adenocarcinoma or squamous cell
carcinoma of the lung

- All samples to be studied were obtained and stored as part of CALGB-140202; the
material and data obtained from the patient's protocol record will be used to obtain
appropriate clinical information

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Patient may not have received neo-adjuvant therapy

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung

Safety Issue:

No

Principal Investigator

Ramaswamy Govindan, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Washington University Siteman Cancer Center

Authority:

Unspecified

Study ID:

CDR0000706375

NCT ID:

NCT01414595

Start Date:

March 2012

Completion Date:

Related Keywords:

  • Lung Cancer
  • adenocarcinoma of the lung
  • adenosquamous cell lung cancer
  • non-small cell lung cancer
  • squamous cell lung cancer
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

Name

Location

Roswell Park Cancer InstituteBuffalo, New York  14263
CCOP - Christiana Care Health ServicesWilmington, Delaware  19899
Rhode Island Hospital Comprehensive Cancer CenterProvidence, Rhode Island  02903
Greenebaum Cancer Center at University of Maryland Medical CenterBaltimore, Maryland  21201
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical CenterLos Angeles, California  90048-1865
Siteman Cancer Center at Barnes-Jewish Hospital - Saint LouisSt. Louis, Missouri  63110
Cancer Institute of New Jersey at Cooper - VoorheesVoorhees, New Jersey  08043
Tunnell Cancer Center at Beebe Medical CenterLewes, Delaware  19958
Union Hospital of Cecil CountyElkton MD, Maryland  21921
Duke Cancer InstituteDurham, North Carolina  27710
Miriam HospitalProvidence, Rhode Island  02906