Inclusion Criteria:

- Histologically confirmed malignancy with presence of intraparenchymal brain
metastases

- Karnofsky performance status ≥ 40

- Measurable disease according to RECIST criteria

- Hematologic function: WBC ≥ 4.0×109/L, PLT ≥ 80×109/L, Hb ≥ 90g/L

- Renal function: Cr ≤ 2.0×ULN

- Hepatic function: BIL ≤ 2.0×ULN, ALT/AST ≤ 5.0×ULN

- Adequate cardiac function

- Life expectancy ≥ 3 months

Exclusion Criteria:

- Evidence of bleeding diathesis or serious infection

- Serious cardiovascular disease (congestive heart failure, uncontrollable arrhythmia,
unstable angina, myocardial infarction, serious heart valve disease, resistant
hypertension)

- Uncontrollable mental and nervous disorders

- Pregnant or lactating women