Inclusion Criteria:

1. Males and females ≥18 years of age.

2. Pathologically confirmed advanced solid tumor or malignant lymphoma for which
standard therapy proven to provide clinical benefit does not exist or is no longer
effective.

3. Eastern Collaborative Oncology Group (ECOG) Performance Status of ≤1

4. Evaluable disease, either measurable on physical examination or imaging by Response
Evaluation Criteria in Solid Tumors (RECIST v1.1), or by the criteria of the
International Working Group (IWG) Revised Response Criteria for Malignant Lymphoma,
or by informative tumor marker(s).

5. Laboratory values at screening:

- Absolute neutrophil count ≥1,500 /mm3;

- Platelets ≥100,000/mm3;

- Total bilirubin ≤1.5 × the upper limit of normal (ULN);

- AST (SGOT) ≤2.5 × the ULN;

- ALT (SGPT) ≤2.5 × the ULN;

- Serum creatinine ≤1.5 mg/dL or a measured creatinine clearance ≥60 mL/min; and

- Negative serum beta-hCG test in women of childbearing potential (defined as
women ≤50 years of age or history of amenorrhea for ≤12 months prior to study
entry).

6. Patients with primary liver cancer or hepatic metastasis are eligible to enroll,
provided that, at screening, the following criteria are met:

- Total bilirubin is no higher than the ULN;

- AST and ALT are each ≤5 × the ULN;

- Severe liver dysfunction (Child-Pugh Class B or C) is not present; and

- Patients with a history of esophageal bleeding have varices that have been
sclerosed or banded and no bleeding episodes have occurred during the prior 6
months.

7. If there is a history of brain metastases treated with radiation therapy, the
radiation therapy must have occurred at least 6 weeks prior to enrolment and the
metastatic disease must have been stable since completion.

8. Willing and able to provide written Informed Consent and comply with the requirements
of the study.

9. In addition, subjects enrolled in the Dose Confirmation Phase must meet the following
criteria:

- For subjects with solid tumors, measurable disease, using RECIST v1.1;

- For subjects with malignant lymphoma, at least 1 lesion clearly measurable and
>1.5cm transverse diameter in 2 perpendicular dimensions, per the criteria for
International Working Group Revised Response Criteria for Malignant Lymphoma;

- No prior treatment with an investigational PI3K, PI3K/mTOR, AKT or mTORC1/mTORC2
inhibitor (prior treatment with temsirolimus, everolimus, or ridaforolimus is
allowed);

- For subjects with colorectal cancer, evidence of lack of mutation in KRAS and
BRAF, unless otherwise approved by the sponsor.

- Tissue block or biopsy confirmation of PI3K alpha mutation on tumor genotyping.

- Tumor accessible for pre- and post-treatment biopsy or cytology (in a subset of
at least 5 subjects in each specific tumor type).

Exclusion Criteria:

1. Any chemotherapy, immunomodulatory drug therapy, anti-neoplastic hormonal therapy,
immunosuppressive therapy, corticosteroids > 20 mg/day prednisone or equivalent
(unless administered to prevent contrast material reactions during radiographic
procedures), or growth factor treatment (eg, erythropoietin) within 14 days prior to
initiation of study drug.

2. Presence of an acute or chronic toxicity of prior chemotherapy, with the exception of
alopecia or peripheral neuropathy, that has not resolved to ≤ Grade 1, as determined
by National Cancer Institute Common Toxicity Criteria for Adverse Events (CTCAE) v
4.0

3. Receipt of more than 5 prior regimens of cytotoxic chemotherapy unless prior approval
is granted by the sponsor.

4. Radiotherapy within 4 weeks prior to baseline.

5. Receipt of radiotherapy to >25 % of bone marrow.

6. History of stem cell allotransplantation.

7. Major surgery within 28 days prior to initiation of study drug.

8. Life expectancy <12 weeks.

9. Active infection requiring systemic therapy.

10. Insulin-requiring diabetes mellitus, or presence of persistent fasting blood glucose
>160 mg/dL.

11. Known human immunodeficiency virus or acquired immunodeficiency syndrome-related
illness.

12. Known active hepatitis B or C or other active liver disease (other than malignancy).

13. Uncontrolled congestive heart failure (New York Heart Association Classification 3 or
4), angina, myocardial infarction, cerebrovascular accident, coronary/peripheral
artery bypass graft surgery, transient ischemic attack, or pulmonary embolism within
3 months prior to initiation of study drug.

14. History of or ongoing cardiac dysrhythmias requiring treatment, atrial fibrillation
of any grade, or persistent prolongation of the QTc (Fridericia) interval to > 450
msec for males or > 470 msec for females.

15. Previous malignancy, except for non-basal-cell carcinoma of skin or carcinoma-in-situ
of the uterine cervix, unless the tumor was treated with curative intent more than 2
years prior to study entry.

16. Concomitant treatment with, or anticipated use of, pharmaceutical or herbal agents
which are potent inhibitors or inducers of cytochrome P450 3A4 enzymes, unless
approved by the sponsor.

17. Use of any investigational agents within 4 weeks of baseline.

18. Pregnant or lactating female.

19. Women of childbearing potential, unless they agree to use dual contraceptive methods
which, in the opinion of the Principal Investigator, are effective and adequate for
that patient's circumstances while on study drug and for 3 months afterward.

20. Men who partner with a woman of childbearing potential, unless they agree to use
effective, dual contraceptive methods (ie, a condom, with female partner using oral,
injectable, or barrier method) while on study drug and for 3 months afterward.

21. Any severe, acute, or chronic medical or psychiatric condition, or laboratory
abnormality that may increase the risk associated with study participation or study
drug administration, may interfere with the informed consent process and/or with
compliance with the requirements of the study, or may interfere with the
interpretation of study results and, in the investigator's opinion, would make the
patient inappropriate for entry into this study.