Inclusion Criteria:

1. Voluntarily signed and dated written informed consent

2. Age ≥ 18 years.

3. Non or minimally daily activities-interfering disease related symptoms.

4. Life expectancy ≥ 3 months.

5. Patients with solid tumor other than CRC.

6. Adequate bone marrow, renal, hepatic, and metabolic function (tests within normal
limits or only minimally altered as assessed ≤ 7 days before inclusion in the
study)Recovery to asymptomatic or minimally altered or to baseline from any adverse
event (AE) derived from previous treatment (mild alteration for alopecia, skin
toxicity or fatigue are allowed).

7. Normal cardiac function cardiac function by appropriate image testing.

8. Women of childbearing potential must have a negative serum pregnancy test before
study entry.

Exclusion Criteria:

1. Primary colorectal cancer diagnosis

2. Prior treatment with PM01183.

3. Concomitant diseases/conditions:

a) History of a clinically relevant cardiac condition c) Known chronic liver disease.
d) Active uncontrolled infection. e) Known human immunodeficiency virus (HIV)
infection. f) Limitation of the patient's ability to comply with the treatment or
follow-up protocol.

4. Symptomatic and progressive or corticosteroid-requiring documented brain metastases

5. Men or women of childbearing potential who are not using an effective method of
contraception as previously described; women who are pregnant or breast feeding.

6. History of extensive prior pelvic irradiation.

7. History of previous bone marrow and/or stem cell transplantation.