Inclusion Criteria:

1. Healthy Men and women, aged from 50 to 75 anos;

2. Phototype I a III (Fitzpatrick Classification);

3. Advanced photoaging on forearms, with multiple superficial actinic keratosis;

4. Agreement with no sun exposure during the study and

5. Agreement with study conditions,capacity to understand and follow the orientations
and form consent signature.

Exclusion Criteria:

1. Topical treatment with:

- tretinoin in the last 6 months ;

- other retinoids, alpha-hydroxyacids, poli-hydroxyacids, beta-hydroxyacids and
ascorbic acid in the last 3 months;

2. Treatment by chemical peeling, microdermabrasion and non-ablative laser in the last
3 months;

3. Treatment with systemic retinoid in the last 6 months ;

4. Chemotherapy in the last 3 months;

5. Hypersensibility to parabens;

6. Infectious or inflammatory dermatosis on forearms;

7. Clinical evidence of immunosuppression and

8. Presence of photodermatosis