Single Nucleotide Polymorphism (SNP)-Based Prediction of Oral Mucositis Risk in Patients Receiving Hematopoietic Stem Cell Transplants
Subjects will be provided with a saliva collection kit which can be used at home. Subjects
will return the collection kit in a paid, pre-addressed mailer to the laboratory at
Biomodels. The laboratory will isolate and store the DNA located in the cells of the saliva.
A portion of this DNA will be used to analyze the different forms of genes. The remainder of
the DNA will be destroyed when this study is completed. Biomodels will not be provided with
The investigators will also collect information from medical records, including information
about diagnosis, treatment, stem cell transplantation and post-transplantation outcomes.
This information will be de-identified.
Observational Model: Cohort, Time Perspective: Retrospective
Develop and validate a clinically applicable SNP-based screening platform for mucositis risk
Develop and validate a clinically applicable SNP-based screening platform that will define mucositis risk among patients undergoing conditioning regimens for HSCT
Joseph Antin, MD
Dana-Farber Cancer Institute
United States: Institutional Review Board
|Dana-Farber Cancer Institute||Boston, Massachusetts 02115|