The Activity of Indoleamine 2,3-dioxygenase in Patients With Chronic Lymphocytic Leukemia (CLL)
The Activity of Indoleamine 2,3-dioxygenase in patients with Chronic Lymphocytic Leukemia
(CLL)is studied in patients and healthly controls.
Observational Model: Case Control, Time Perspective: Prospective
IDO activity and expression measured by kynurenine/tryptophan ratio in serum and by PCR in peripheral blood mononuclear cells.
Indoleamine 2,3 -dioxygenase (IDO) activity in patients with CLL was measured by the serum kynurenine/tryptophan (kyn/trp) ratio and - the expression of INDO (encoding IDO enzyme) and INDOL1 (encoding IDO2 enzyme) genes in peripheral blood mononuclear cells via TaqMan real-time PCR.
Marjatta Sinisalo, MD, PhD
Tampere University Hospital
Finland: Finnish Medicines Agency