Inclusion Criteria:

1. Patients with c-KIT mutated histologically proven advanced mucosal or acral melanoma
in which the mutation is not known to be associated with nilotinib resistance.

2. Advanced mucosal and acral melanoma defined as unresectable locally advanced or
metastatic disease

3. The presence of one or more clinically or radiologically measurable lesions at least
10mm in size

4. Age 18 or greater

5. ECOG performance status 0, 1 or 2

6. Life expectancy greater than 12 weeks

7. At least 14 days since any major surgery

8. The capacity to understand the patient information sheet and ability to provide
written informed consent

9. Willingness and ability to comply with scheduled visits, treatment plans, laboratory
tests and other study procedures

10. Women must not be pregnant or lactating with no intention of pregnancy during study
treatment. Women of child bearing potential must have a negative serum pregnancy
test prior to study entry (even if surgically sterilised). Men and women of
childbearing potential must use adequate birth control measures (e.g. abstinence,
oral contraceptives, intrauterine device, barrier method with spermicide, implantable
or injectable contraceptives or surgical sterilisation) for the duration of the study
and should continue such precautions for 6 months after receiving the last study
treatment

11. Serum alanine transaminase (ALT) or serum aspartate aminotransferase ≤2.5 x upper
limit of normal (ULN) and total serum bilirubin ≤1.5 x ULN

12. Serum creatinine ≤1.5 x ULN

13. Serum lipase and amylase <1.5 x ULN

14. Haemoglobin ≥9.0 g/dL, absolute neutrophil count ≥1.5 x 109/L, platelets ≥100 x 109/L

15. Prothrombin time (PT) ≤1.5 x ULN

16. Able to swallow and retain oral medication.

Exclusion Criteria:

1. Intracranial disease, unless there has been radiological evidence of stable
intracranial disease > 6 months. In the case of a solitary brain metastasis, evidence
of a disease-free interval of at least 3 months post surgery. All patients
previously treated for brain metastases must be stable off corticosteroid therapy for
at least 28 days

2. Women who are pregnant, nursing, or planning to become pregnant during the course of
the trial

3. Men who plan to father a child during the course of the trial

4. Use of any investigational drug within 30 days prior to screening (both cancer and
non cancer treatments)

5. Use of herbal or chinese medication

6. Use of therapeutic coumarin derivatives (ie warfarin, acenocoumarol, phenprocoumon)

7. Significant cardiac disease including patients who have or who are at significant
risk of developing prolongation of QTc

8. Severe and/or uncontrolled medical disease

9. Known chronic liver disease

10. Past medical history of chronic pancreatitis

11. Known HIV infection

12. Previous radiotherapy to 25% or more of the bone marrow

13. Radiation therapy in the 4 weeks prior to study entry

14. Prior exposure to a tyrosine kinase inhibitor

15. Known lactose intolerance

16. Any malabsorption syndrome (i.e. partial gastrectomy, small bowel resection, Crohn's
disease or ulcerative colitis).