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Search for Predictors of Therapeutic Response in Patients With Carcinoma of the Ovary, the Fallopian Tube or Peritoneal Serous-type Advanced


N/A
18 Years
N/A
Open (Enrolling)
Female
Carcinoma of the Ovary, Fallopian Tube Cancer, Peritoneal Serous-type Advanced Stage

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Trial Information

Search for Predictors of Therapeutic Response in Patients With Carcinoma of the Ovary, the Fallopian Tube or Peritoneal Serous-type Advanced


Inclusion Criteria:



- Patients with cancer of the ovary, peritoneum or of the fallopian tube

- Stage III or IV

- Cancer of serous histology

- Patients of any chemotherapy naive

- Patients should receive treatment with chemotherapy for first line by Taxol-
Carboplatin. Avastin is authorized in concomitant.

- An initial surgery or through authorized

- Patients who signed informed consent

- Patients over the age of 18 years

Exclusion Criteria:

- Patients being treated for another cancer chemotherapy and / or hormone therapy

- Patients receiving other chemotherapy Taxol-carboplatin associated or not to avastin

- Patients under guardianship

- Previous history of pelvic radiotherapy

- History of malignancy blood

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label

Outcome Measure:

search for predictors of response to chemotherapy

Outcome Description:

the search for predictors of response to chemotherapy in patients with carcinoma of the ovary, the fallopian tube or peritoneal serous-type advanced by using (i) the miRNA profile of serum before treatment with chemotherapy and (ii) the identification of polymorphisms or SNPs (Single Nucleotide polymorphism) in particular genes involved in the metabolism of chemotherapy agents

Outcome Time Frame:

12 months after beginning treatment

Safety Issue:

No

Principal Investigator

Florence JOLY-LOBBEDEZ, PD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre François Baclesse

Authority:

France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:

miRSa

NCT ID:

NCT01391351

Start Date:

June 2011

Completion Date:

March 2015

Related Keywords:

  • Carcinoma of the Ovary
  • Fallopian Tube Cancer
  • Peritoneal Serous-type Advanced Stage
  • carcinoma of the ovary, the fallopian tube or peritoneal serous-type advanced stage
  • chemotherapy with Taxol and Carboplatin
  • predictors of therapeutic response
  • serum miRNA
  • identification of polymorphisms or SNPs (Single Nucleotide Polymorphism)
  • Carcinoma
  • Fallopian Tube Neoplasms
  • Neoplasms, Glandular and Epithelial
  • Ovarian Neoplasms

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