Inclusion Criteria:

- Aged above 18 years.

- ECOG performance status 0, 1 or 2.

- Pathologically confirmed metastatic colorectal cancer.

- Failure of Second-Line or Above Treatment, and irinotecan- and
oxaliplatin--containing regimens (If recurrence and metastasis occurred within 6
months after discontinuation of adjuvant chemotherapy, the adjuvant chemotherapy is
considered to be first-line treatment). more than 4 weeks before enrollment after
discontinuation of chemotherapy.

- Minimum of 4 weeks since any local radiotherapy or surgery for the control of
symptoms or severe complications(local radiotherapy for the control of bone
metastases is not the limit)，and adequately recovered from toxicities of any prior
therapy).

- At least one measurable lesion according to the RECIST criteria that has not been
previously local treated. Minimum indicator lesion size as follows: greater than or
equal to 10 mm measured by spiral CT or NMR.

- The organ function is normal (laboratory test results came within 1 week before
administration in the absence of ongoing supportive care): ANC ≥ 1.5 x 109/L,
Platelets ≥ 80 x 109/L, Hgb ≥ 8.5 g/dL, serum total bilirubin ≤ 1.5 x upper limit of
normal (ULN), and serum AST and ALT ≤ 2.5 x ULN(≤ 5 x ULN if liver metastases), serum
creatinine ≤1.5 x ULN.

- Have been fully aware of the study and voluntarily signed the informed consent.

- Life expectancy of at least 3 months.

Exclusion Criteria:

- Pregnancy or breast-feeding women or women who may be pregnant were positive drug
test before administration.

- Patient of child-bearing potential(male or less than 1 year postmenopausal women)
were reluctant to take contraceptive measures.

- Patient who were allergic to Interferon-α or who had interferon-α antibody.

- Patients with uncontrolled central nervous system (CNS) metastases.

- Patient with any other Malignant tumors within five years (except for a complete cure
of carcinoma in situ of the cervix or basal cell cancer or squamous cell skin
cancer).

- Patient with Clinically uncontrolled active infection such as acute pneumonia, active
hepatitis B, etc.

- Patient associated with Significant Systemic illness including, but not limited to,
the following: cerebrovascular disease, uncontrolled diabetes, uncontrolled
hypertension, acute myocardial infarction, unstable angina, Congestive heart failure
,serious dysrhythmias, metabolic diseases, thrombosis or thromboembolic events
occurred(including transient ischemic attack) in the last 6 months.

- Patient with serious autoimmune diseases in the past or at present, such as systemic
lupus erythematosus, rheumatoid arthritis, thyroiditis, etc.

- Patient with ascites, pleural and pericardial effusion that cannot be controlled by
drainage or symptomatic treatment.

- Investigator think Patient is not appropriate to participate in this trial for any
clinical or laboratory abnormalities, or patient with any grade ≥ 2 toxicity
according to NCI CTC AE 3.0 standard .

- Patient who also are accepting other systemic anti-tumor therapy (local radiotherapy
for the control of bone metastases is not the limit)), in this study received 4 weeks
before the start of drug treatment of other tests.

- Patient who had serious psychological or psychiatric disorder or Drug addiction or
alcohol dependence.

- Patient who are estimated to be lack of compliance in this study.

- Patient with acute or subacute intestinal obstruction.