Inclusion Criteria:

1. Active uveitis associated with juvenile idiopathic arthritis, with the exclusion of
systemic JIA, juvenile-onset rheumatoid arthritis, and enthesitis-related JIA

2. Uveitis resistant to well conducted topical steroid therapy comprising either
dexamethasone or rimexolone at a dose adapted to the patient's situation as validated
by one of the investigating ophthalmologists.

3. Failure of systemic treatment with methotrexate at a dose of 0.3 to 0.6 mg.kg
(without exceeding 25 mg) once a week for at least 3 months (except in the case of
methotrexate intolerance).

4. Patient who can be evaluated by laser flare photometry.

5. Patient at least 4 years old on initiation of trial medication and weighing a minimum
of 15 kg

6. Signed informed consent both parents and/or patient's agreement

7. Patient has a social security or similar

Exclusion Criteria:

1. Systemic JIA, juvenile-onset rheumatoid arthritis, enthesitis-related JIA (with a
risk of red eye uveitis).

2. History of treatment with anti-TNF alpha monoclonal antibody (either adalimumab or
infliximab).

3. Any contraindication to administration of immunosuppressive therapy (immune deficit,
opportunistic infection, other severe chronic disease)

- History of cancer or lymphoproliferative disease other than successfully and
completely resected squamous cell or basal cell skin cancer,

- Any uncontrolled disease: unstable diabetes with documented history of recurrent
infections, unstable ischaemic heart disease, moderate to severe heart failure
(NYHA stage III/IV), recent stroke and any other disease or condition inducing,
in the investigator's opinion, a risk for the patient related to his/her
participation in the trial,

- Positive hepatitis B or C serology indicating active infection,

- History of positive HIV serology,

- Persistent infection or severe infections requiring hospitalisation or IV
antibiotic therapy during the 30 days prior to inclusion in the trial or oral
antibiotic therapy during the 14 days prior to inclusion in the trial,

- History of clinically significant alcohol or other substance abuse during the
previous year,

- Previous diagnosis or signs of demyelinating disease of the central nervous
system,

- History of active tuberculosis, histoplasmosis or listeriosis,

- Signs of latent tuberculosis (based on a history of nontreated contamination, or
an opacity greater than 1 cm on chest x-ray, or a positive intradermal reaction
to 5 IU of tuberculin ≥ 5 mm).

- Negative urine pregnancy test in girls with childbearing potential

4. Chronic rupture of the blood-aqueous barrier with marked flare on the initial
examination but not modified by one month of anti-inflammatory therapy.

5. Impossibility to monitor flare:

- Children < 4 years

- False flare due to the presence of giant cells on the surface of an artificial
lens or in an aphakic child.

6. Children presenting complications such as refractory glaucoma or cataract rapidly
requiring surgery.

7. Phthisis bulbi with hypotonia and atrophy of the ciliary body.

8. Any other situation raising problems for maintenance of stable doses of steroids and
immunosuppressive drugs during the period between 4 weeks before D0 and the M2
evaluation. Authorized immunosuppressive therapies that must be maintained at stable
dose are steroid eye drops, systemic steroid therapy and once weekly oral or
subcutaneous MTX at a dose of 0.3 to 0.6 mg (without exceeding 25 mg).

9. Any ophthalmologic contraindication

10. If female and childbearing potential should have an appropriate contraceptive method
during all study period and 5 months after last adalimumab dose. Abstinence with no
oral contraception can be considered.