Inclusion Criteria:

Subjects Receiving Chemotherapy:

- Have a diagnosis of invasive breast cancer (stage I-IIIC) or intermediate or
high-grade* lymphoma (*defined by the treating physician)

- Be scheduled to begin a course of chemotherapy

- Oral chemotherapy is acceptable

- Previous or concurrent treatment with hormones or biological response modifiers is
acceptable. (Subjects receiving biological response modifiers only are not eligible).

- Be chemotherapy naïve

- Life expectancy greater than 10 months

- Be able to speak and read English

- Give written informed consent

Inclusion Criteria, Controls:

- Must be the same gender as the subject receiving chemotherapy

- Must be within 5 years of the age of the subject receiving chemotherapy

- Life expectancy greater than 10 months

- Be able to speak and read English

- Give written informed consent

- Must be willing to participate in the study for the entire period

Exclusion Criteria:

Subjects Receiving Chemotherapy:

- Must not be currently hospitalized or have been hospitalized within the last year for
a psychiatric illness

- Must not be diagnosed with a neurodegenerative disease

- Must not have primary central nervous system (CNS) disease

- Must not have received chemotherapy in the past

- Must not be scheduled to receive concurrent radiation treatment

- Must not have metastatic disease (subjects with breast cancer)

- Must not be pregnant

- Must not be colorblind

Exclusion Criteria, Controls:

- Must not be currently hospitalized or have been hospitalized within the last year for
a psychiatric illness

- Must not be diagnosed with a neurodegenerative disease

- Must not have primary CNS disease

- Must not have been diagnosed with cancer or previously have received chemotherapy

- Must not be pregnant or plan on becoming pregnant during the study period

- Must not be colorblind