Trial Information

The Effect and Mechanism of Improving Diabetes by Reconstruction Methods in Gastric Cancer Patients With DM Who Receive Surgical Treatment

Purpose:

- To investigate the effect of gastrectomy on remission of type 2 diabetes in patients
with gastric cancer and type 2 diabetes

- To investigate the mechanism of blood glucose alteration and intestinal hormonal
signaling by the reconstruction methods

- To evaluate the applicability and efficacy of Roux-en-Y gastrojejunostomy after
gastrectomy in gastric cancer patients with diabetes

Contents:

- Evaluation of the status of diabetes in gastric cancer patients with DM after
gastrectomy

- Comparison of two reconstruction types after gastrectomy Bypass duodenum and upper
jejunum: Roux-en-Y gastrojejunostomy Preservation of duodenal passage:
Gastroduodenostomy

- Analysis for biochemical markers reflecting diabetic status: fasting glucose,
postprandial 2h glucose, HbA1c, C-peptide, lipid profile

- Correlation of parameters associated with diabetes and GI hormones

- Measurement of GI hormones which have an effect on glucose tolerance

- Insulin, glucagon, IGF-1, GLP-1, Neuropeptide Y, Ghrelin, Leptin

- Correlation of reconstruction methods, parameters of diabetes and GI hormone
levels

- Evaluation of mechanism of Roux-en-Y gastrojejunostomy on controlling diabetes

- Evaluation of Feasibility of Roux-en-Y gastrojejunostomy in gastric cancer surgery in
patients with DM

- Degree of high blood glucose control, the amount of antidiabetic medication, costs
for DM treatment, quality of life assessment

- Analysis for the mechanism of gastrointestinal physiology to diabetes control