Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response of the Lung With Cancer Undergoing Lobectomy. A Randomised Placebo-controlled Trial
Pulmonary lobectomy induces an inflammatory response of this lung caused by intraoperative
atelectasis and re-expansion. This inflammatory response can be attenuated with treatment,
also decreasing postoperative pulmonary complications (PPC). Thus, avoiding complete
atelectasis with partial insufflation of the lung during surgery could be useful to decrease
inflammatory response and PPC.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.
Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.
From preoperative to postoperative (24h) period.
Yes
Spain: Comité Ético de Investigación Clínica
INFLATOR
NCT01368601
May 2011
May 2014
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