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Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response of the Lung With Cancer Undergoing Lobectomy. A Randomised Placebo-controlled Trial


N/A
18 Years
80 Years
Open (Enrolling)
Both
Lung Cancer

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Trial Information

Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response of the Lung With Cancer Undergoing Lobectomy. A Randomised Placebo-controlled Trial


Pulmonary lobectomy induces an inflammatory response of this lung caused by intraoperative
atelectasis and re-expansion. This inflammatory response can be attenuated with treatment,
also decreasing postoperative pulmonary complications (PPC). Thus, avoiding complete
atelectasis with partial insufflation of the lung during surgery could be useful to decrease
inflammatory response and PPC.


Inclusion Criteria:



- Adults (18-80 aged) with American Society of Anesthesiologists physical status I-III,
scheduled to undergo elective thoracic surgery with lung resection performed through
thoracotomy, and requiring OLV (one lung ventilation)during surgery.

Exclusion Criteria:

- Ongoing treatment with any dose of systemic or topical steroids, acute pulmonary or
extrapulmonary infections (elevated C-reactive protein [CRP]), history of recurrent
pneumothoraces, previous thoracic surgery.

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.

Outcome Description:

Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.

Outcome Time Frame:

From preoperative to postoperative (24h) period.

Safety Issue:

Yes

Authority:

Spain: Comité Ético de Investigación Clínica

Study ID:

INFLATOR

NCT ID:

NCT01368601

Start Date:

May 2011

Completion Date:

May 2014

Related Keywords:

  • Lung Cancer
  • Lung Cancer
  • CPAP
  • PPC
  • lobectomy
  • One-lung ventilation
  • Lung Neoplasms

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