Comparison of Protective Manual Hyperinflation With Current Methods in Ventilated Acute Trauma Patients: a Randomized Controlled Trial
18 Years
N/A
Both
Critically Injured Mechanically Ventilated Trauma Patients
Trial Information
Comparison of Protective Manual Hyperinflation With Current Methods in Ventilated Acute Trauma Patients: a Randomized Controlled Trial
Current evidence in mechanical ventilation supports a "protective lung strategy" that is,
smaller tidal volumes and prevention of loss of positive end expiratory pressure (PEEP).
There is concern that manual hyperinflation (MHI) may conflict with this strategy and cause
volutrauma and atelectrauma potentially leading to biotrauma.
This single-blinded randomized study aims to compare two methods of manual hyperinflation
(protective - moderate tidal volumes with positive end expiratory pressure) and
non-protective (large tidal volume and no positive end expiratory pressure) in ventilated
acute trauma patients, to investigate the effect on inflammatory markers, lung compliance,
oxygenation and sputum volume.
Inclusion Criteria:
- Trauma patients
- Day 1 of admission to intensive care
- Mechanically ventilated
Exclusion Criteria:
- Pre-existing lung disease
- PEEP > 12.5cmH20
- Nitric oxide in circuit
- Haemodynamically unstable
- Undrained pneumothorax
- Intracranial pressure > 25mmHg
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
Outcome Measure:
Interleukin 6
Outcome Description:
5 mls of arterial blood will be colected in an EDTA tube, centrifuged and aliquoted within 30 minutes. It will be stored at -80 degrees C and the analysis completed in batches by enzyme linked immunosorbent assay
Outcome Time Frame:
Change between Baseline and 40 minutes and 70 minutes post baseline
Safety Issue:
No
Authority:
Australia: Human Research Ethics Committee
Study ID:
PMH1
NCT ID:
NCT01366274
Start Date:
September 2007
Completion Date:
December 2011
Related Keywords:
- Critically Injured Mechanically Ventilated Trauma Patients
- Trauma
- Wounds and Injuries
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