Investigation to Evaluate the Levels of Human Germinal-center-Associated Lymphoma (HGAL) Protein in Pediatric Hodgkin Lymphoma and Correlate With Early Response
- To investigate the variability of expression of human geminal-center-associated
lymphoma (HGAL) protein in pediatric low-risk Hodgkin lymphoma.
- To assess the variability of HGAL staining between risk groups by comparing samples
from subjects enrolled in the low-risk study AHOD0431 with subject samples enrolled in
AHOD0031 for intermediate-risk classical Hodgkin Lymphoma (cHL).
- To assess the variability of HGAL staining by evaluating a tissue array created from
subjects with intermediate-risk cHL.
- To correlate rapid or slow early-response in the intermediate-risk group with HGAL
OUTLINE: Paraffin-embedded tissue samples and tissue microarrays are analyzed for protein
expression by IHC.
Variability of HGAL protein expression in pediatric patients with low-risk classical Hodgkin lymphoma (cHL)
Frank G. Keller, MD
Emory Children's Center - Atlanta
United States: Federal Government