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Investigation to Evaluate the Levels of Human Germinal-center-Associated Lymphoma (HGAL) Protein in Pediatric Hodgkin Lymphoma and Correlate With Early Response


N/A
N/A
21 Years
Open (Enrolling)
Both
Lymphoma

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Trial Information

Investigation to Evaluate the Levels of Human Germinal-center-Associated Lymphoma (HGAL) Protein in Pediatric Hodgkin Lymphoma and Correlate With Early Response


OBJECTIVES:

- To investigate the variability of expression of human geminal-center-associated
lymphoma (HGAL) protein in pediatric low-risk Hodgkin lymphoma.

- To assess the variability of HGAL staining between risk groups by comparing samples
from subjects enrolled in the low-risk study AHOD0431 with subject samples enrolled in
AHOD0031 for intermediate-risk classical Hodgkin Lymphoma (cHL).

- To assess the variability of HGAL staining by evaluating a tissue array created from
subjects with intermediate-risk cHL.

- To correlate rapid or slow early-response in the intermediate-risk group with HGAL
protein expression.

OUTLINE: Paraffin-embedded tissue samples and tissue microarrays are analyzed for protein
expression by IHC.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosed with low-risk classical Hodgkin lymphoma (cHL)

- Samples available from patients enrolled in the low-risk study COG-AHOD0431 and in
the intermediate-risk cHL study COG-AHOD0031

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Variability of HGAL protein expression in pediatric patients with low-risk classical Hodgkin lymphoma (cHL)

Safety Issue:

No

Principal Investigator

Frank G. Keller, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Emory Children's Center - Atlanta

Authority:

United States: Federal Government

Study ID:

CDR0000701020

NCT ID:

NCT01366157

Start Date:

May 2011

Completion Date:

Related Keywords:

  • Lymphoma
  • childhood favorable prognosis Hodgkin lymphoma
  • stage I childhood Hodgkin lymphoma
  • stage II childhood Hodgkin lymphoma
  • stage III childhood Hodgkin lymphoma
  • stage IV childhood Hodgkin lymphoma
  • childhood lymphocyte depletion Hodgkin lymphoma
  • childhood lymphocyte predominant Hodgkin lymphoma
  • childhood mixed cellularity Hodgkin lymphoma
  • childhood nodular lymphocyte predominant Hodgkin lymphoma
  • childhood nodular sclerosis Hodgkin lymphoma
  • Hodgkin Disease
  • Lymphoma

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