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A Study to Assess and Quantify Surface Insulin-like Growth Factor I Receptor (IGF-IR) in Rhabdomyosarcoma (RMS) Tumor Tissue


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Sarcoma

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Trial Information

A Study to Assess and Quantify Surface Insulin-like Growth Factor I Receptor (IGF-IR) in Rhabdomyosarcoma (RMS) Tumor Tissue


OBJECTIVES:

- To determine and quantify the degree of surface insulin-like growth factor I receptor
(IGF-IR) expression in rhabdomyosarcoma (RMS) tumor tissue.

- To assess the feasibility and validity of a mass spectrometry assay for IGF-IR
expression on paraffin-embedded tumor tissue.

OUTLINE: Paraffin-embedded tumor tissue slides are analyzed for insulin-like growth factor I
receptor (IGF-1R) expression by mass spectrometry and correlated with the results obtained
by IHC assay.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of rhabdomyosarcoma

- Alveolar or embryonal rhabdomyosarcoma

- Available samples from the Cooperative Human Tissue Network (CHTN) bank

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Degree of surface IGF-IR expression in RMS tumor tissue

Safety Issue:

No

Principal Investigator

Suman Malempati, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Doernbecher Children's Hospital at Oregon Health and Science University

Authority:

United States: Federal Government

Study ID:

CDR0000701015

NCT ID:

NCT01365962

Start Date:

June 2011

Completion Date:

Related Keywords:

  • Sarcoma
  • alveolar childhood rhabdomyosarcoma
  • embryonal childhood rhabdomyosarcoma
  • previously treated childhood rhabdomyosarcoma
  • previously untreated childhood rhabdomyosarcoma
  • recurrent childhood rhabdomyosarcoma
  • Rhabdomyosarcoma
  • Sarcoma

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