French National Prospective Cohort of Children With Port Wine Stain on a Limb = "Cohorte Nationale d'Enfants Avec Angiome Plan de Membre inférieur"
Prospective national study, including 16 Pediatric and Dermatologic Departments.
Methods : each children with a port wine stain on a lower limb will be followed up for 5
Collected data : demographic data, clinical features, alterations of RASA1 gene, vascular
evaluation by ultrasonographic and orthopedic evaluation by X rays, quality of life with a
Inclusion period = 3 years Follow up period = 5 years Population = 150 children
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
complicated evolution (defined as: vascular, orthopedic or systemic involvement linked with the port wine stain)
during the 5 years of follow up
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
PHRN09 - GL / CONAPE