Inclusion Criteria:

1. Subjects must provide written informed consent prior to performance of study-specific
procedures or assessments which are not routinely performed for diagnosis or
monitoring of acute myeloid leukemia (AML), and the subjects must be willing to
comply with treatment and to follow up assessments and procedures

2. Histologically or cytologically confirmed diagnosis of AML relapsed after or
refractory to at least one induction regimen, or patients with AML at initial
diagnosis who are not eligible for allogeneic transplant or intensive induction
chemotherapy, except for AML M3 (acute promyelocytic leukemia)

3. Age at least 18 years

4. Eastern Cooperative Oncology Group (ECOG) performance status of ≤3

5. Measurable disease burden (blasts in BM and/or PB, extramedullary blasts [chloroma])

6. Able to swallow and retain oral medication

7. A life expectancy of at least 4 weeks

8. Adequate contraception methods

9. Adequate organ function as defined in the study protocol

Exclusion Criteria:

1. Patients with a valid option for intensive chemotherapy and/or stem cell
transplantation (Patients after allogeneic stem cell transplant must be off
immunosuppressive agents for at least 2 weeks prior to study entry and Graft-versus
host disease must have resolved to Grade ≤2)

2. History of cancer that according to the Investigator might confound the assessment of
the endpoints of the study

3. Uncontrolled peptic ulcer disease or clinically significant gastrointestinal
abnormalities which interfere with oral dosing or any unstable or serious concurrent
condition (e.g., active uncontrolled infection)

4. Poorly controlled hypertension [defined as systolic blood pressure (SBP) of ≥140 mmHg
or diastolic blood pressure (DBP) of ≥90 mmHg]. Note: Initiation or adjustment of
antihypertensive medication(s) is permitted prior to study entry. BP must be
re-assessed on two occasions that are separated by a minimum of 1 hour; on each of
these occasions, the mean (of 3 readings) SBP / DBP values from each BP assessment
must be <140/90 mmHg in order for a subject to be eligible for the study

5. Prolongation of corrected QT interval (QTc) >480 milliseconds

6. History of any one of more of the following cardiovascular conditions within the past
6 months: cardiac angioplasty or stenting, myocardial infarction, unstable angina,
symptomatic peripheral vascular disease, class III or IV congestive heart failure, as
defined by the New York Heart Association (NYHA)

7. History of cerebrovascular infarction or bleeding, pulmonary embolism, or untreated
deep venous thrombosis (DVT) within the past 6 months. Note: Subjects with recent DVT
who have been treated with therapeutic anti-coagulant agents for at least 6 weeks are
eligible

8. Evidence of serious active bleeding or bleeding diathesis (except for bleeding or
petechiae due to AML-related thrombocytopenia which will be treated using platelet
transfusions). Also, patients with known endobronchial lesions and/or lesions
infiltrating major pulmonary vessels will be excluded from the study due to excess
risk of bleeding.

9. Prior major surgery or trauma within 28 days prior to first dose of study drug

10. Treatment with an investigational agent within 28 days or 5 half-lives, whichever is
longer prior to the first dose of study drug (for bevacizumab 60 days).

11. Concurrent cytoreductive chemotherapy (hydroxyurea must be discontinued at least one
day before start of study medication)

12. Known immediate or delayed hypersensitivity reaction or idiosyncrasy to pazopanib

13. Patients with psychological, familial, sociological, or geographical conditions that
do not permit compliance with the protocol

14. Pregnant or lactating and actively breastfeeding patients

15. Patients taking any of the following prohibited medication:

- clarithromycin, telithromycin, troleandomycin (antibiotics)

- ritonavir, indinavir, saquinavir, nelfinavir, amprenavir, lopinavir (HIV
protease inhibitors)

- itraconazole, ketoconazole, voriconazole, fluconazole (antifungals)

- nefazodone (antidepressant)