Inclusion Criteria:

- Patients at least 18 years old presenting with histopathologically or cytologically
confirmed metastatic adenocarcinoma of the pancreas; metastatic disease is defined as
disease which has spread beyond the peri-pancreatic lymph nodes.

- Patients must have received no prior chemotherapy for pancreatic cancer, including
adjuvant chemotherapy.

- Measurable disease, defined as lesions that can be accurately measured in at least 1
dimension with longest diameter (LD) ≥20 mm using conventional techniques or ≥10 mm
with spiral computed tomography (CT) scan; measurable lymph nodes must be ≥15 mm in
the short axis.

- ECOG Performance Status of 0, 1, or 2.

- Patients must have adequate renal function and serum creatinine ≤2.0 mg/dL.

- Patients must have adequate liver function as defined by total bilirubin ≤2.0 mg/dL
and transaminase levels no higher than 3.0 times the institution's upper limit of
normal (ULN). Patients with hepatic metastases may have transaminase levels of up to
5.0 times the ULN.

- All patients must have a serum albumin ≥3.0 g/dL.

- Patients must have adequate bone marrow (BM) function as defined by a granulocyte
count ≥1,500/mm3, a platelet count ≥100,000/mm3, and hemoglobin >9 g/dL.

- Disease-free period of more than 5 years from prior malignancies other than pancreas
(except curatively treated basal cell carcinoma, squamous cell carcinoma of the skin,
or carcinoma in situ of the cervix and ductal carcinoma in situ [DCIS] breast
disease).

- Adequate contraceptive regimen (including prescription oral contraceptives [birth
control pills], contraceptive injections, intrauterine device [IUD], double-barrier
method [spermicidal jelly or foam with condoms or diaphragm], contraceptive patch, or
surgical sterilization) before entry and throughout the study for female patients of
reproductive potential or female partners of male patients.

- Female patient with reproductive potential must have a negative urine beta human
chorionic gonadotropin (bHCG) pregnancy test at Screening.

- Willing to adhere to the prohibitions and restrictions specified in this protocol.

- Patient must have signed an informed consent document.

Exclusion Criteria:

- Patients with unresectable locally advanced disease without evidence of disease
elsewhere.

- Life expectancy of less than 12 weeks.

- Uncontrolled intercurrent illness including, but not limited to, symptomatic
congestive heart failure, unstable angina pectoris, cardiac arrhythmia, uncontrolled
hypertension or seizure disorder.

- Active infection not adequately responding to appropriate therapy.

- Symptomatic or clinically evident ascites.

- Serum sodium less than 130 mEq/L or conditions that may predispose patients to
hyponatremia.

- Female patients who are pregnant or lactating.

- Male patients with female sexual partners who are unwilling to follow the strict
contraception requirements described in this protocol.

- Major surgery without full recovery or major surgery within 3 weeks of ON 01910.Na
treatment start.

- Evidence of brain metastases.

- Any concurrent administration and/or prior administration within 4 weeks of the first
dose of study drug, of radiotherapy, or immunotherapy.

- Psychiatric illness/social situations that would limit the patient's ability to
tolerate and/or comply with study requirements, or inability to comply with study
and/or follow-up procedures (e.g., drug addition, chronic non-compliance, etc.).