Inclusion Criteria

Inclusion criteria:

Patient with advanced solid tumors for which there is no approved or curative therapy:

- has any advanced solid tumor with diagnosed alteration in 1 or more genes of the
PI3K, and mitogen-activated protein kinase (MAPK) pathways and/or

- has a histologically or cytologically confirmed diagnosis of 1 of the following solid
tumors: pancreatic, thyroid, colorectal, non-small cell lung, endometrial, renal,
breast, ovarian carcinoma and melanoma

Exclusion criteria:

The patient has previously been treated with a PI3K inhibitor or a Mitogen-activated
protein extracellular signal-regulated kinase (MEK) inhibitor

The patient has received:

- Chemotherapy, immunotherapy, hormonal therapy, biologic therapy, or any other
anticancer therapy within 28 days or 5 half lives for noncytotoxics (whichever is
shorter) of Day 1 of trial drug treatment (6 weeks for nitrosureas or mitomycin C)

- Any investigational agent within 28 days of Day 1 of trial drug treatment The patient
is currently receiving anticoagulation therapy with therapeutic doses of warfarin
(low-dose warfarin ≤1 mg/day, heparin, and low-molecular weight heparins are
permitted) History of central nervous system metastases The patient has had
congestive heart failure, unstable angina, a myocardial infarction, cardiac
conduction abnormality or pacemaker or a stroke within 3 months of entering the
study. The patient has retinal degenerative disease (hereditary retinal degeneration
or age-related macular degeneration), history of uveitis, or history of retinal vein
occlusion, or has medically relevant abnormalities identified on screening
ophthalmologic examination.

The above information is not intended to contain all considerations relevant to a
patient's potential participation in a clinical trial.