Inclusion Criteria:

- Untreated, histologically confirmed, KRAS wild type, resectable gastric or esophageal
adenocarcinoma

- T2-4 NX M0 disease

- ECOG performance status 0-1

- adequate hematological status

- adequate renal function

- adequate hepatic function

- adequate metabolic function

Exclusion Criteria:

- pregnant or breast feeding women

- previous malignancy other than gastric cancer in the last 5 years except curatively
treated basal cell carcinoma of the skin and/or in situ carcinoma of the cervix

- arterial or venous thromboembolism within 6 months before enrollment

- clinically significant cardiovascular disease within 1 year before enrollment

- history of interstitial lung disease